A Second Infusion (Early Reinfusion) of Tisagenlecleucel in Children and Young Adults With B-Cell Acute Lymphoblastic Leukemia(B-ALL)

Save

Report Abuse

Description

The researchers are doing this study to see if early reinfusion of tisagenlecleucel can keep participants in B-CEll ApLasia at 6 months after their first infusion. The researchers will also look at the safety of early reinfusion and how effective it is at treating B-ALL.

Study Overview

Start Date
July 12, 2022
Completion Date
July 1, 2026
Enrollment
33
Date Posted
July 15, 2022
Accepts Healthy Volunteers?
No
Gender
All

Locations

Full Address
Children's Hospital of Los Angeles (Data Collection Only)
Los Angeles, California 90027, United States

Stanford University (Data Collection Only)
Stanford, California 94305, United States

Children's Hospital Colorado (Data Collection Only)
Aurora, Colorado 80045, United States

Johns Hopkins University (Data Collection Only)
Baltimore, Maryland 21287, United States

Memorial Sloan Kettering Cancer Center
New York, New York 10065, United States

Cincinnati Children's Hospital Medical Center (Data Collection Only)
Cincinnati, Ohio 45229, United States

Eligibility

Maximum Age (years)
25
Eligibility Criteria
Inclusion Criteria:

Patients with R/R B-ALL who have received commercial tisagenlecleucel and have (an) additional dose(s) available for early reinfusion
History of CD19 expressing (in peripheral blood or bone marrow by flow cytometry) BALL prior to tisagenlecleucel infusion
Peripheral blood B-cell aplasia (BCA) within 14 days prior to reinfusion (See section 13.8: B-cell aplasia will be defined as peripheral blood (PB) absolute B lymphocyte count ≤ 50/μL. If BCA evaluation is repeated at any timepoint prior to reinfusion, it must be negative to proceed with reinfusion
Minimal residual disease negative complete remission (CR/CRi) in bone marrow within 14 days prior to reinfusion, including resolution of extramedullary disease

Patients with tisagenlecleucel that is deemed out of specification (OOS) will be permitted on this protocol if the reason for OOS is deemed to not impact the toxicity and efficacy profile of CAR T cell therapy

°Reasons for product being OOS include cell viability < 80%, total nucleated cell count <2 × 10^9 in leukapheresis product, failed interferon-γ release assay, leukapheresis product collected >9 months prior, and determination of residual beads >50 beads per 3 × 10^6 cells

Patients age: < 26 years at time of first tisagenlecleucel order placement

Recovered from severe toxicities following initial dose of tisagenlecleucel

CRS
Neurotoxicity/ICANS

Adequate organ function at time of treatment is required and is defined:

Hepatic: Serum bilirubin ≤ 2 mg/dL, unless benign congenital hyperbilirubinemia
Hepatic: AST and ALT < 5x the upper limit of normal for age, unless thought to be disease-related
Renal: Serum creatinine <1.5x normal for age. If serum creatinine is outside the normal range, then CrCl > 60 mL/min/1.73m2 (calculated or estimated) or GFR (mL/min/1.72m2 ) >55% of predicted normal for age

Age Mean GFR +/-SD (mL/min/1.73 m2)

1 week 40.6 + / - 14.8
2 - 8 weeks 65.8 + / - 24.8
> 8 weeks 95.7 +/- 21.7
2 - 12 years 133 +/- 27
13 - 21 years (males) 140 +/- 30

13 - 21 years (females) 126.0 + / - 22.0 Abbreviations: GFR, glomerular filtration rate; SD, standard deviation. Greater than 2 years old: Normal GFR is 100 mL/ min. Infants: GFR must be corrected for body surface area.

Cardiac: LVEF ≥ 50% by multi-gated acquisition scan (MUGA), resting echocardiogram, or cardiac magnetic resonance imaging (MRI) within 6 weeks of screening
Pulmonary: Oxygen saturation as recorded by pulse oximetry of ≥ 90% on room air

Adequate performance status:

Age ≥ 16 years: ECOG ≤ 1 or Karnofsky > 60% at treatment
Age < 16 years: Lansky > 60% at treatment
Patient must be enrolled on institutional CIBMTR reporting protocol for immune effector cells (IEC)/CAR T cells
Each patient must be willing to participate as a research subject, and patient or legal guardian must sign an informed consent form, along with patient assent if between 7 to 17 years of age. Legally authorized representatives of adult patients with impaired decision-making capacity will also be able to sign consent.

Exclusion Criteria:

Greater than 60 days from first tisagenlecleucel infusion
Ongoing severe toxicities from initial CAR T cell infusion
Received non-standard lymphodepleting chemotherapy (LDC) prior to initial tisagenlecleucel dose

Standard LDC is defined as:

Fludarabine 30mg/m^2/dose x 4 doses
Cyclophosphamide 500mg/m^2/dose x 2 doses
Loss of BCA at any timepoint prior to reinfusion
Clinically significant active infection confirmed by clinical evidence, imaging, or positive laboratory tests (e.g., blood cultures, PCR for DNA/RNA, etc.)
Patient/parent/guardian unable to give informed consent or unable to comply with the treatment protocol
Pregnant or lactating women; women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception while taking study treatment and for at least 12 months after the tisagenlecleucel infusion and until CAR T-cells are no longer present by flow cytometry on two consecutive tests.
Sexually active males, unless they are willing to use a condom during intercourse while taking study treatment and for at least 12 months after the tisagenlecleucel infusion and until CAR T-cells are no longer present by flow cytometry on two consecutive tests.
Other uncontrolled, symptomatic, intercurrent illness including but not limited to infection, psychiatric illness, or social situations that would limit compliance with study requirements or in the opinion of the PI would pose an unacceptable risk to the subject
Any other issue which, in the opinion of the treating physician, would make the patient ineligible for the study

Study Contact Info

Study Contact Name
Kevin Curran, MD; Kavitha Ramaswamy, MD
Study Contact Email
Study Contact Phone

Contact Listings Owner Form

A Second Infusion (Early Reinfusion) of Tisagenlecleucel in Children and Young Adults With B-Cell Acute Lymphoblastic Leukemia(B-ALL) 0 reviews

Write Your Review

There are no reviews yet.

Write Your Review

Your email address will not be published. Required fields are marked *

Other Details

FDA Regulated Drug?
Yes
FDA Regulated Device?
No
Detailed Description
Prior to initial tisagenlecleucel cell infusion, lymphodepleting chemotherapy (LDC) is required with standard dosing cyclophosphamide and fludarabine as per standard-of-care (fludarabine 30mg/m^2 /dose x 4 doses and cyclophosphamide 500mg/m^2 /dose x 2 doses). Dose adjustments based off ideal body weight (IBW) and/or per institutional guidelines are allowed. LDC should be completed 2 to 14 days prior to the first tisagenlecleucel infusion. LDC may be repeated in cases where tisagenlecleucel has been delayed by more than 4 weeks. No additional LDC will be given prior to the early reinfusion.
NCTid (if applicable)
NCT05460533