Effects of Dietary Polystyrene Microplastics on Anxiety- and Depression-like Behaviors

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Description

The objective of this clinical trial is to explore the potential impact of dietary polystyrene microplastics on anxiety- and depression-like behaviors in resident physicians. Specifically, the study aims to address two key questions:

Can dietary polystyrene microplastics induce alterations in the human gut microbiome?
Can dietary polystyrene microplastics exacerbate anxiety- and depression-like behaviors?

Participants will be divided into two groups based on their habitual eating practices: The control group, consisting of resident physicians, will use non-disposable plastic tableware (NDPT) provided by hospital canteens for two months. In contrast, the exposure group, also comprising resident physicians, will use disposable plastic tableware (DPT) made of polystyrene, provided by the same hospital canteens, over the same period.

Targeted Conditions

Study Overview

Start Date
January 1, 2024
Completion Date
May 1, 2024
Enrollment
15
Date Posted
February 8, 2024
Accepts Healthy Volunteers?
Yes
Gender
All

Locations

Full Address
Ju Gao
Yangzhou, Jiangsu 225001, China

Eligibility

Minimum Age (years)
20
Maximum Age (years)
30
Eligibility Criteria
Inclusion Criteria:

Volunteer resident physician at the base of Northern Jiangsu Hospital, Yangzhou, China

Exclusion Criteria:

received chemotherapy, radiotherapy, or surgery in the 3 -6 months before sampling
diagnosed with mental illness
diagnosed with digestive system diseases

Study Contact Info

Study Contact Name
Ju Gao
Study Contact Email
Study Contact Phone

Contact Listings Owner Form

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Other Details

FDA Regulated Drug?
No
FDA Regulated Device?
No
Detailed Description
The mental health and well-being of resident physicians is a critical topic that has gained increasing attention recently. Recent studies have shown a growing prevalence of mental health illnesses worldwide. For medical trainees and resident physicians, high rates of depression, anxiety, suicidal ideation, and burnout have been consistently observed. Moreover, contemporary research suggests that dietary exposure plays a pivotal role in the development of mental illnesses. Disposable plastic tableware, commonly used during resident training programs, could be a contributing factor. However, the specific effects of dietary exposure from such tableware on mental health, particularly through the gut-brain axis, remain largely unexplored. Consequently, investigating the potential impact of dietary polystyrene microplastics on anxiety- and depression-like behaviors in resident physicians is essential.
NCTid (if applicable)
NCT06247579