Home Rehabilitation After Acute Pulmonary Embolism


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The purpose of this study is to evaluate whether a home rehabilitation program after hospitalization for acute pulmonary embolism (PE) improves clinical outcomes at 3 months compared to usual care. Daily physical activity tasks that incorporate heart rate monitoring will be sent through email or text. This information could help improve the management of acute PE.

Targeted Conditions

Study Overview

Start Date
December 19, 2022
Completion Date
June 1, 2025
Date Posted
October 7, 2022
Accepts Healthy Volunteers?


Full Address
University of Rochester Medical Center
Rochester, New York 14642, United States


Minimum Age (years)
Eligibility Criteria
Inclusion Criteria:

English speaking (>18 years old). Daily messages will be sent in English.
Acute PE with right ventricular enlargement or dysfunction defined by echocardiogram report, CT Angiogram report, or elevated cardiac biomarker (NT-pro BNP or troponin).
Baseline testing started within 7 days of hospital discharge.

Exclusion Criteria:

Cardiac Effort >2.5 beats/m during 6MWT. This is for safety.
Cardiac Effort <1.2 beats/m during 6MWT. They are unlikely to benefit.
Resting tachycardia >120 beats/m during screening or at hospital discharge.
Suspicion for Chronic Thromboembolic Pulmonary Hypertension.
Systolic blood pressure >180 mmHg during screening or at hospital discharge.
Inability to walk.
Estimated prognosis <12 months at the time of discharge due to underlying co-morbidities.
Advanced neurologic disease.
Lack of access to email or text messaging.
Inability to follow daily instructions.
Participation in a structured exercise routine at least three days per week in the prior four weeks.
Principal Investigator discretion

Study Contact Info

Study Contact Name
Daniel Lachant, DO; Alyssa R Williams, BS
Study Contact Phone

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Other Details

FDA Regulated Drug?
FDA Regulated Device?
NCTid (if applicable)