To evaluate the efficacy and safety of sunbathing and Bifidobacterium alone or in combination for full-term neonates with hyperbilirubinemia. The investigators hypothesize that the combination therapy of sunbathing plus Bifidobacterium is safe and effective for prevention and management of hyperbilirubinemia in full-term neonates. The investigators therefore design this prospective, randomized, controlled study to assess the preventive effects of sunbathing combined with Bifidobacterium supplementation on hyperbilirubinemia in full-term neonates. These observations may provide scientific evidence for the use of sunbathing and Bifidobacterium supplementation in the management of hyperbilirubinemia in full-term neonates.
Zhuhai, Guangdong 519000, China
Term infants with 37 weeks ≤ gestational age < 42 weeks and 2500g ≤ birth weight < 4000g
Age ≤24 hours
Stable basic vital signs
Liver and kidney function normal
No prior use of antibiotics or ecological agents before specimen collection
Healthy mothers during pregnancy, with no history of antibiotics or microecological agents before, during, or after childbirth
Informed consent provided voluntarily.
Gestational age <37 weeks or ≥42 weeks
Complications present with pneumonia, septicemia, or other illness
Severe immunodeficiency disease present
Inherited metabolic diseases identified
Congenital biliary malformations or other organ malformations
History of asphyxiation
Before enteral feeding, constipation, abdominal distension, diarrhea, vomiting or other gastrointestinal symptoms had appeared
Enteral feeding was not performed
Antibiotics or other microecological agents were used
Isoimmune hemolysis, extravascular hemolysis, polycythemia, erythrocyte enzyme deficiency, erythrocyte morphological abnormality, hemoglobinopathy, etc.
Hyperbilirubinemia were diagnosed within 24 hours of birth
Situations that may warrant exclusion as determined by the researcher, such as a guardian with mental illness or frequent changes in living or working environments, which might result in loss of follow-up
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