Quantification of Dilutional Anemia in the Initial Phase of Sepsis Management: Preliminary Retrospective Study


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This is a single-center retrospective study conducted at Mercy hospital, aiming to investigate the correlation between changes in hemoglobin (Hb) levels and the volume of vascular refill administered during the first 48 hours.

Targeted Conditions

Study Overview

Start Date
January 1, 2024
Completion Date
March 1, 2024
Date Posted
February 5, 2024
Accepts Healthy Volunteers?


Full Address
CHR Metz-Thionville/Hopital Mercy
Metz 57085, France


Study Population
Septic patients
Minimum Age (years)
Eligibility Criteria
Inclusion Criteria:

Patients with septic shock, admitted to Mercy hospital between November 1, 2022 and July 31, 2023, with Noradrenaline administration for at least 6 hours and at least 2 hemoglobin measurements during the first 48 hours of resuscitation.

Exclusion Criteria:

patients with acute bleeding or blood transfusion before or during the first 48 hours of resuscitation.

Study Contact Info

Study Contact Name
Arpiné EL NAR, PhD
Study Contact Phone

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Other Details

FDA Regulated Drug?
FDA Regulated Device?
Detailed Description
Vascular refill is central to the initial management of hypotension in sepsis, and is often started even before the patient is admitted to intensive care. Over the past 20 years, we have moved from ultraliberal fluid resuscitation to restrictive resuscitation. Indeed, in the early 2000s, the implementation of an early and aggressive hemodynamic optimization strategy, including liberal vascular filling, improved the survival of critically ill patients, and ushered in the era of the Surviving Sepsis Campaign. However, studies have shown increased morbidity and mortality associated with a positive fluid balance. Restrictive approaches to fluid resuscitation and/or deressuscitation were then tested. While these approaches failed to demonstrate any benefit in terms of mortality, they did have the merit of demonstrating their feasibility and good tolerability, albeit with a little-explored pathophysiology. Little is known about the problem of dilutional anemia in the acute phase of septic shock.
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