Ramucirumab Plus Pembrolizumab vs Usual Care for Treatment of Stage IV or Recurrent Non-Small Cell Lung Cancer Following Immunotherapy, Pragmatica-Lung Study

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Description

This phase III trial compares the effect of the combination of ramucirumab and pembrolizumab versus standard of care chemotherapy for the treatment of non-small cell lung cancer that is stage IV or that has come back after a period of improvement (recurrent). Ramucirumab is a monoclonal antibody that may prevent the growth of new blood vessels that tumors need to grow. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. This trial may help doctors find out if giving ramucirumab with pembrolizumab is more effective at treating patients with stage IV or recurrent non-small cell lung cancer than standard chemotherapy.

Study Overview

Start Date
March 14, 2023
Completion Date
March 15, 2028
Enrollment
700
Date Posted
December 1, 2022
Accepts Healthy Volunteers?
No
Gender
All

Locations

Full Address
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama 35233, United States

University of South Alabama Mitchell Cancer Institute
Mobile, Alabama 36688, United States

Banner University Medical Center - Tucson
Tucson, Arizona 85719, United States

University of Arizona Cancer Center-North Campus
Tucson, Arizona 85719, United States

Mercy Hospital Fort Smith
Fort Smith, Arkansas 72903, United States

John L McClellan Memorial Veterans Hospital
Little Rock, Arkansas 72205, United States

University of Arkansas for Medical Sciences
Little Rock, Arkansas 72205, United States

Highlands Oncology Group - Rogers
Rogers, Arkansas 72758, United States

Highlands Oncology Group
Springdale, Arkansas 72762, United States

Kaiser Permanente-Anaheim
Anaheim, California 92806, United States

PCR Oncology
Arroyo Grande, California 93420, United States

Sutter Auburn Faith Hospital
Auburn, California 95602, United States

Kaiser Permanente-Baldwin Park
Baldwin Park, California 91706, United States

Kaiser Permanente-Bellflower
Bellflower, California 90706, United States

Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California 94704, United States

Tower Cancer Research Foundation
Beverly Hills, California 90211, United States

Marshall Cancer Center
Cameron Park, California 95682, United States

City of Hope Comprehensive Cancer Center
Duarte, California 91010, United States

Kaiser Permanente Dublin
Dublin, California 94568, United States

Kaiser Permanente-Fontana
Fontana, California 92335, United States

Kaiser Permanente-Fremont
Fremont, California 94538, United States

Palo Alto Medical Foundation-Fremont
Fremont, California 94538, United States

Kaiser Permanente - Harbor City
Harbor City, California 90710, United States

City of Hope at Huntington Beach
Huntington Beach, California 92648, United States

City of Hope at Irvine Lennar
Irvine, California 92618, United States

Kaiser Permanente-Irvine
Irvine, California 92618, United States

City of Hope Antelope Valley
Lancaster, California 93534, United States

Loma Linda University Medical Center
Loma Linda, California 92354, United States

City of Hope at Long Beach Elm
Long Beach, California 90813, United States

Kaiser Permanente Los Angeles Medical Center
Los Angeles, California 90027, United States

Kaiser Permanente West Los Angeles
Los Angeles, California 90034, United States

Cedars Sinai Medical Center
Los Angeles, California 90048, United States

Fremont - Rideout Cancer Center
Marysville, California 95901, United States

Memorial Medical Center
Modesto, California 95355, United States

Kaiser Permanente-Modesto
Modesto, California 95356, United States

City of Hope Newport Beach
Newport Beach, California 92660, United States

Kaiser Permanente-Oakland
Oakland, California 94611, United States

Kaiser Permanente-Ontario
Ontario, California 91761, United States

Palo Alto Medical Foundation Health Care
Palo Alto, California 94301, United States

Kaiser Permanente - Panorama City
Panorama City, California 91402, United States

Kaiser Permanente-Riverside
Riverside, California 92505, United States

Kaiser Permanente-Roseville
Roseville, California 95661, United States

Sutter Roseville Medical Center
Roseville, California 95661, United States

Kaiser Permanente Downtown Commons
Sacramento, California 95814, United States

Sutter Medical Center Sacramento
Sacramento, California 95816, United States

University of California Davis Comprehensive Cancer Center
Sacramento, California 95817, United States

Kaiser Permanente-South Sacramento
Sacramento, California 95823, United States

Kaiser Permanente-San Diego Zion
San Diego, California 92120, United States

California Pacific Medical Center-Pacific Campus
San Francisco, California 94115, United States

Kaiser Permanente-San Francisco
San Francisco, California 94115, United States

Kaiser Permanente-Santa Teresa-San Jose
San Jose, California 95119, United States

Kaiser Permanente San Leandro
San Leandro, California 94577, United States

Kaiser Permanente-San Marcos
San Marcos, California 92078, United States

Kaiser San Rafael-Gallinas
San Rafael, California 94903, United States

Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California 95051, United States

Palo Alto Medical Foundation-Santa Cruz
Santa Cruz, California 95065, United States

Kaiser Permanente-Santa Rosa
Santa Rosa, California 95403, United States

City of Hope South Pasadena
South Pasadena, California 91030, United States

Kaiser Permanente-South San Francisco
South San Francisco, California 94080, United States

Palo Alto Medical Foundation-Sunnyvale
Sunnyvale, California 94086, United States

Torrance Memorial Physician Network - Cancer Care
Torrance, California 90505, United States

Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee, California 96161, United States

City of Hope Upland
Upland, California 91786, United States

Kaiser Permanente-Vallejo
Vallejo, California 94589, United States

Sutter Solano Medical Center/Cancer Center
Vallejo, California 94589, United States

Kaiser Permanente-Walnut Creek
Walnut Creek, California 94596, United States

Presbyterian Intercommunity Hospital
Whittier, California 90602, United States

Kaiser Permanente-Woodland Hills
Woodland Hills, California 91367, United States

Rocky Mountain Regional VA Medical Center
Aurora, Colorado 80045, United States

UCHealth University of Colorado Hospital
Aurora, Colorado 80045, United States

UCHealth Memorial Hospital Central
Colorado Springs, Colorado 80909, United States

Memorial Hospital North
Colorado Springs, Colorado 80920, United States

Kaiser Permanente-Franklin
Denver, Colorado 80205, United States

Poudre Valley Hospital
Fort Collins, Colorado 80524, United States

Cancer Care and Hematology-Fort Collins
Fort Collins, Colorado 80528, United States

UCHealth Greeley Hospital
Greeley, Colorado 80631, United States

Kaiser Permanente-Rock Creek
Lafayette, Colorado 80026, United States

Kaiser Permanente-Lone Tree
Lone Tree, Colorado 80124, United States

UCHealth Lone Tree Health Center
Lone Tree, Colorado 80124, United States

Medical Center of the Rockies
Loveland, Colorado 80538, United States

Smilow Cancer Hospital-Derby Care Center
Derby, Connecticut 06418, United States

Smilow Cancer Hospital Care Center-Fairfield
Fairfield, Connecticut 06824, United States

Smilow Cancer Hospital Care Center at Glastonbury
Glastonbury, Connecticut 06033, United States

Smilow Cancer Hospital Care Center at Greenwich
Greenwich, Connecticut 06830, United States

Smilow Cancer Hospital Care Center - Guilford
Guilford, Connecticut 06437, United States

Hartford Hospital
Hartford, Connecticut 06102, United States

Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut 06105, United States

Midstate Medical Center
Meriden, Connecticut 06451, United States

The Hospital of Central Connecticut
New Britain, Connecticut 06050, United States

Yale University
New Haven, Connecticut 06520, United States

Yale-New Haven Hospital North Haven Medical Center
North Haven, Connecticut 06473, United States

Smilow Cancer Hospital-Orange Care Center
Orange, Connecticut 06477, United States

Smilow Cancer Hospital Care Center at Long Ridge
Stamford, Connecticut 06902, United States

Stamford Hospital/Bennett Cancer Center
Stamford, Connecticut 06904, United States

Smilow Cancer Hospital-Torrington Care Center
Torrington, Connecticut 06790, United States

Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut 06611, United States

Smilow Cancer Hospital-Waterbury Care Center
Waterbury, Connecticut 06708, United States

Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut 06385, United States

Veterans Affairs Connecticut Healthcare System-West Haven Campus
West Haven, Connecticut 06516, United States

Beebe South Coastal Health Campus
Frankford, Delaware 19945, United States

Helen F Graham Cancer Center
Newark, Delaware 19713, United States

Medical Oncology Hematology Consultants PA
Newark, Delaware 19713, United States

Beebe Health Campus
Rehoboth Beach, Delaware 19971, United States

Kaiser Permanente-Capitol Hill Medical Center
Washington, District of Columbia 20002, United States

MedStar Georgetown University Hospital
Washington, District of Columbia 20007, United States

MedStar Washington Hospital Center
Washington, District of Columbia 20010, United States

UM Sylvester Comprehensive Cancer Center at Aventura
Aventura, Florida 33180, United States

UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida 33146, United States

UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida 33442, United States

Malcom Randall Veterans Administration Medical Center
Gainesville, Florida 32610, United States

The Watson Clinic
Lakeland, Florida 33805, United States

Mount Sinai Medical Center
Miami Beach, Florida 33140, United States

University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida 33136, United States

UM Sylvester Comprehensive Cancer Center at Plantation
Plantation, Florida 33324, United States

Moffitt Cancer Center-International Plaza
Tampa, Florida 33607, United States

Moffitt Cancer Center
Tampa, Florida 33612, United States

Northside Hospital
Atlanta, Georgia 30342, United States

Northside Hospital - Duluth
Duluth, Georgia 30096, United States

Eisenhower Army Medical Center
Fort Gordon, Georgia 30905-5650, United States

Northeast Georgia Medical Center-Gainesville
Gainesville, Georgia 30501, United States

Northside Hospital - Gwinnett
Lawrenceville, Georgia 30046, United States

Memorial Health University Medical Center
Savannah, Georgia 31404, United States

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia 31405, United States

Tift Regional Medical Center
Tifton, Georgia 31794, United States

South Georgia Medical Center/Pearlman Cancer Center
Valdosta, Georgia 31602, United States

Hawaii Cancer Care - Westridge
'Aiea, Hawaii 96701, United States

Pali Momi Medical Center
'Aiea, Hawaii 96701, United States

Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu, Hawaii 96813, United States

Queen's Cancer Cenrer - POB I
Honolulu, Hawaii 96813, United States

Queen's Medical Center
Honolulu, Hawaii 96813, United States

Straub Clinic and Hospital
Honolulu, Hawaii 96813, United States

Queen's Cancer Center - Kuakini
Honolulu, Hawaii 96817, United States

Kaiser Permanente Moanalua Medical Center
Honolulu, Hawaii 96819, United States

Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho 83706, United States

Saint Luke's Cancer Institute - Boise
Boise, Idaho 83712, United States

Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho 83605, United States

Kootenai Health - Coeur d'Alene
Coeur d'Alene, Idaho 83814, United States

Saint Luke's Cancer Institute - Fruitland
Fruitland, Idaho 83619, United States

Saint Luke's Cancer Institute - Meridian
Meridian, Idaho 83642, United States

Saint Luke's Cancer Institute - Nampa
Nampa, Idaho 83686, United States

Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho 83687, United States

Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho 83854, United States

Kootenai Cancer Clinic
Sandpoint, Idaho 83864, United States

Saint Luke's Cancer Institute - Twin Falls
Twin Falls, Idaho 83301, United States

Rush - Copley Medical Center
Aurora, Illinois 60504, United States

Advocate Good Shepherd Hospital
Barrington, Illinois 60010, United States

Illinois CancerCare-Bloomington
Bloomington, Illinois 61704, United States

Illinois CancerCare-Canton
Canton, Illinois 61520, United States

Illinois CancerCare-Carthage
Carthage, Illinois 62321, United States

Northwestern University
Chicago, Illinois 60611, United States

University of Illinois
Chicago, Illinois 60612, United States

Swedish Covenant Hospital
Chicago, Illinois 60625, United States

Advocate Illinois Masonic Medical Center
Chicago, Illinois 60657, United States

AMG Crystal Lake - Oncology
Crystal Lake, Illinois 60014, United States

Carle at The Riverfront
Danville, Illinois 61832, United States

Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois 62526, United States

Decatur Memorial Hospital
Decatur, Illinois 62526, United States

Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois 60115, United States

Illinois CancerCare-Dixon
Dixon, Illinois 61021, United States

Advocate Good Samaritan Hospital
Downers Grove, Illinois 60515, United States

Carle Physician Group-Effingham
Effingham, Illinois 62401, United States

Crossroads Cancer Center
Effingham, Illinois 62401, United States

Advocate Sherman Hospital
Elgin, Illinois 60123, United States

Illinois CancerCare-Eureka
Eureka, Illinois 61530, United States

NorthShore University HealthSystem-Evanston Hospital
Evanston, Illinois 60201, United States

Illinois CancerCare-Galesburg
Galesburg, Illinois 61401, United States

Northwestern Medicine Cancer Center Delnor
Geneva, Illinois 60134, United States

NorthShore University HealthSystem-Glenbrook Hospital
Glenview, Illinois 60026, United States

Advocate South Suburban Hospital
Hazel Crest, Illinois 60429, United States

NorthShore University HealthSystem-Highland Park Hospital
Highland Park, Illinois 60035, United States

Edward Hines Jr VA Hospital
Hines, Illinois 60141, United States

Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois 61443, United States

Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois 60045, United States

AMG Libertyville - Oncology
Libertyville, Illinois 60048, United States

Condell Memorial Hospital
Libertyville, Illinois 60048, United States

Illinois CancerCare-Macomb
Macomb, Illinois 61455, United States

Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938, United States

Loyola University Medical Center
Maywood, Illinois 60153, United States

Cancer Care Center of O'Fallon
O'Fallon, Illinois 62269, United States

Advocate Christ Medical Center
Oak Lawn, Illinois 60453-2699, United States

Northwestern Medicine Orland Park
Orland Park, Illinois 60462, United States

Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350, United States

Advocate Lutheran General Hospital
Park Ridge, Illinois 60068, United States

Illinois CancerCare-Pekin
Pekin, Illinois 61554, United States

Illinois CancerCare-Peoria
Peoria, Illinois 61615, United States

Illinois CancerCare-Peru
Peru, Illinois 61354, United States

Illinois CancerCare-Princeton
Princeton, Illinois 61356, United States

Memorial Hospital East
Shiloh, Illinois 62269, United States

Southern Illinois University School of Medicine
Springfield, Illinois 62702, United States

Springfield Clinic
Springfield, Illinois 62702, United States

Memorial Medical Center
Springfield, Illinois 62781, United States

Carle Cancer Center
Urbana, Illinois 61801, United States

Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois 60555, United States

Illinois CancerCare - Washington
Washington, Illinois 61571, United States

Rush-Copley Healthcare Center
Yorkville, Illinois 60560, United States

Northwest Cancer Center - Main Campus
Crown Point, Indiana 46307, United States

Northwest Oncology LLC
Dyer, Indiana 46311, United States

Northwest Cancer Center - Hobart
Hobart, Indiana 46342, United States

Saint Mary Medical Center
Hobart, Indiana 46342, United States

Saint Catherine Hospital
Indianapolis, Indiana 46312, United States

The Community Hospital
Munster, Indiana 46321, United States

Women's Diagnostic Center - Munster
Munster, Indiana 46321, United States

Memorial Hospital of South Bend
South Bend, Indiana 46601, United States

Northwest Cancer Center - Valparaiso
Valparaiso, Indiana 46383, United States

University of Iowa Healthcare Cancer Services Quad Cities
Bettendorf, Iowa 52722, United States

Mercy Hospital
Cedar Rapids, Iowa 52403, United States

Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa 52403, United States

Medical Oncology and Hematology Associates-Des Moines
Des Moines, Iowa 50309, United States

Mercy Medical Center - Des Moines
Des Moines, Iowa 50314, United States

HaysMed University of Kansas Health System
Hays, Kansas 67601, United States

Lawrence Memorial Hospital
Lawrence, Kansas 66044, United States

Olathe Health Cancer Center
Olathe, Kansas 66061, United States

Freeman Physician Group of Pittsburg
Pittsburg, Kansas 66762, United States

Salina Regional Health Center
Salina, Kansas 67401, United States

University of Kansas Health System Saint Francis Campus
Topeka, Kansas 66606, United States

Ascension Via Christi Hospitals Wichita
Wichita, Kansas 67214, United States

King's Daughter's Medical Center
Ashland, Kentucky 41101, United States

University of Kentucky/Markey Cancer Center
Lexington, Kentucky 40536, United States

Owensboro Health Mitchell Memorial Cancer Center
Owensboro, Kentucky 42303, United States

Louisiana Hematology Oncology Associates LLC
Baton Rouge, Louisiana 70809, United States

Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana 70809, United States

Terrebonne General Medical Center
Houma, Louisiana 70360, United States

University Medical Center New Orleans
New Orleans, Louisiana 70112, United States

Greater Baltimore Medical Center
Baltimore, Maryland 21204, United States

Sinai Hospital of Baltimore
Baltimore, Maryland 21215, United States

Kaiser Permanente-Woodlawn Medical Center
Baltimore, Maryland 21244, United States

UPMC Western Maryland
Cumberland, Maryland 21502, United States

Kaiser Permanente-Gaithersburg Medical Center
Gaithersburg, Maryland 20879, United States

Kaiser Permanente - Largo Medical Center
Largo, Maryland 20774, United States

Kaiser Permanente Lutherville - Timonium Medical Center
Lutherville, Maryland 21093, United States

William E Kahlert Regional Cancer Center/Sinai Hospital
Westminster, Maryland 21157, United States

Beverly Hospital
Beverly, Massachusetts 01915, United States

Boston Medical Center
Boston, Massachusetts 02118, United States

Lahey Hospital and Medical Center
Burlington, Massachusetts 01805, United States

Addison Gilbert Hospital
Gloucester, Massachusetts 01930, United States

Lahey Medical Center-Peabody
Peabody, Massachusetts 01960, United States

Baystate Medical Center
Springfield, Massachusetts 01199, United States

Winchester Hospital
Winchester, Massachusetts 01890, United States

Saint Joseph Mercy Hospital
Ann Arbor, Michigan 48106, United States

University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan 48109, United States

Bronson Battle Creek
Battle Creek, Michigan 49017, United States

Saint Joseph Mercy Brighton
Brighton, Michigan 48114, United States

Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, Michigan 48114, United States

Saint Joseph Mercy Canton
Canton, Michigan 48188, United States

Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, Michigan 48188, United States

Saint Joseph Mercy Chelsea
Chelsea, Michigan 48118, United States

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, Michigan 48118, United States

Ascension Saint John Hospital
Detroit, Michigan 48236, United States

Great Lakes Cancer Management Specialists-Doctors Park
East China Township, Michigan 48054, United States

Green Bay Oncology - Escanaba
Escanaba, Michigan 49829, United States

Genesee Cancer and Blood Disease Treatment Center
Flint, Michigan 48503, United States

Genesee Hematology Oncology PC
Flint, Michigan 48503, United States

Genesys Hurley Cancer Institute
Flint, Michigan 48503, United States

Hurley Medical Center
Flint, Michigan 48503, United States

Spectrum Health at Butterworth Campus
Grand Rapids, Michigan 49503, United States

Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Grosse Pointe Woods, Michigan 48236, United States

Bronson Methodist Hospital
Kalamazoo, Michigan 49007, United States

West Michigan Cancer Center
Kalamazoo, Michigan 49007, United States

Ascension Borgess Cancer Center
Kalamazoo, Michigan 49009, United States

Borgess Medical Center
Kalamazoo, Michigan 49048, United States

Sparrow Hospital
Lansing, Michigan 48912, United States

Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan 48154, United States

Great Lakes Cancer Management Specialists-Macomb Medical Campus
Macomb, Michigan 48044, United States

Trinity Health Muskegon Hospital
Muskegon, Michigan 49444, United States

Cancer and Hematology Centers of Western Michigan - Norton Shores
Norton Shores, Michigan 49444, United States

Saint Joseph Mercy Oakland
Pontiac, Michigan 48341, United States

Corewell Health Reed City Hospital
Reed City, Michigan 49677, United States

Lakeland Medical Center Saint Joseph
Saint Joseph, Michigan 49085, United States

Marie Yeager Cancer Center
Saint Joseph, Michigan 49085, United States

Bhadresh Nayak MD PC-Sterling Heights
Sterling Heights, Michigan 48312, United States

Munson Medical Center
Traverse City, Michigan 49684, United States

Advanced Breast Care Center PLLC
Warren, Michigan 48088, United States

Great Lakes Cancer Management Specialists-Macomb Professional Building
Warren, Michigan 48093, United States

Macomb Hematology Oncology PC
Warren, Michigan 48093, United States

Michigan Breast Specialists-Warren
Warren, Michigan 48093, United States

Saint John Macomb-Oakland Hospital
Warren, Michigan 48093, United States

University of Michigan Health - West
Wyoming, Michigan 49519, United States

Huron Gastroenterology PC
Ypsilanti, Michigan 48106, United States

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan 48197, United States

Sanford Joe Lueken Cancer Center
Bemidji, Minnesota 56601, United States

Mercy Hospital
Coon Rapids, Minnesota 55433, United States

Fairview Southdale Hospital
Edina, Minnesota 55435, United States

Fairview Clinics and Surgery Center Maple Grove
Maple Grove, Minnesota 55369, United States

Abbott-Northwestern Hospital
Minneapolis, Minnesota 55407, United States

Hennepin County Medical Center
Minneapolis, Minnesota 55415, United States

New Ulm Medical Center
New Ulm, Minnesota 56073, United States

Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota 55416, United States

Regions Hospital
Saint Paul, Minnesota 55101, United States

United Hospital
Saint Paul, Minnesota 55102, United States

Rice Memorial Hospital
Willmar, Minnesota 56201, United States

Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus, Mississippi 39705, United States

Baptist Cancer Center-Grenada
Grenada, Mississippi 38901, United States

Gulfport Memorial Hospital
Gulfport, Mississippi 39502, United States

Baptist Memorial Hospital and Cancer Center-Union County
New Albany, Mississippi 38652, United States

Baptist Memorial Hospital and Cancer Center-Oxford
Oxford, Mississippi 38655, United States

Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, Mississippi 38671, United States

Saint Francis Medical Center
Cape Girardeau, Missouri 63703, United States

Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri 63141, United States

Parkland Health Center - Farmington
Farmington, Missouri 63640, United States

Truman Medical Centers
Kansas City, Missouri 64108, United States

Saint Luke's Hospital of Kansas City
Kansas City, Missouri 64111, United States

Kansas City Veterans Affairs Medical Center
Kansas City, Missouri 64128, United States

Saint Luke's East - Lee's Summit
Lee's Summit, Missouri 64086, United States

Washington University School of Medicine
Saint Louis, Missouri 63110, United States

Veteran's Affairs Medical Center - Saint Louis
Saint Louis, Missouri 63125, United States

Mercy Hospital South
Saint Louis, Missouri 63128, United States

Siteman Cancer Center-South County
Saint Louis, Missouri 63129, United States

Missouri Baptist Medical Center
Saint Louis, Missouri 63131, United States

Siteman Cancer Center at Christian Hospital
Saint Louis, Missouri 63136, United States

Mercy Hospital Saint Louis
Saint Louis, Missouri 63141, United States

Siteman Cancer Center at Saint Peters Hospital
Saint Peters, Missouri 63376, United States

Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri 63670, United States

Mercy Hospital Springfield
Springfield, Missouri 65804, United States

Missouri Baptist Sullivan Hospital
Sullivan, Missouri 63080, United States

BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri 63127, United States

Community Hospital of Anaconda
Anaconda, Montana 59711, United States

Billings Clinic Cancer Center
Billings, Montana 59101, United States

Bozeman Deaconess Hospital
Bozeman, Montana 59715, United States

Benefis Healthcare- Sletten Cancer Institute
Great Falls, Montana 59405, United States

Kalispell Regional Medical Center
Kalispell, Montana 59901, United States

Community Medical Hospital
Missoula, Montana 59804, United States

OptumCare Cancer Care at Charleston
Las Vegas, Nevada 89102, United States

OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada 89148, United States

Renown Regional Medical Center
Reno, Nevada 89502, United States

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire 03756, United States

Cooper Hospital University Medical Center
Camden, New Jersey 08103, United States

Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus
Elizabeth, New Jersey 07207, United States

Jersey City Medical Center
Jersey City, New Jersey 07302, United States

Monmouth Medical Center Southern Campus
Lakewood, New Jersey 08701, United States

Saint Barnabas Medical Center
Livingston, New Jersey 07039, United States

Monmouth Medical Center
Long Branch, New Jersey 07740, United States

Virtua Samson Cancer Center
Moorestown, New Jersey 08057, United States

Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey 08903, United States

Newark Beth Israel Medical Center
Newark, New Jersey 07112, United States

Robert Wood Johnson University Hospital Somerset
Somerville, New Jersey 08876, United States

Community Medical Center
Toms River, New Jersey 08755, United States

MD Anderson Cancer Center at Cooper-Voorhees
Voorhees, New Jersey 08043, United States

Virtua Voorhees
Voorhees, New Jersey 08043, United States

University of New Mexico Cancer Center
Albuquerque, New Mexico 87102, United States

Montefiore Medical Center-Einstein Campus
Bronx, New York 10461, United States

Montefiore Medical Center-Weiler Hospital
Bronx, New York 10461, United States

Montefiore Medical Center - Moses Campus
Bronx, New York 10467, United States

Arnot Ogden Medical Center/Falck Cancer Center
Elmira, New York 14905, United States

Garnet Health Medical Center
Middletown, New York 10940, United States

Mount Sinai Chelsea
New York, New York 10011, United States

Mount Sinai Hospital
New York, New York 10029, United States

Upstate Cancer Center at Oswego
Oswego, New York 13126, United States

University of Rochester
Rochester, New York 14642, United States

Stony Brook University Medical Center
Stony Brook, New York 11794, United States

State University of New York Upstate Medical University
Syracuse, New York 13210, United States

SUNY Upstate Medical Center-Community Campus
Syracuse, New York 13215, United States

Upstate Cancer Center at Verona
Verona, New York 13478, United States

Wilmot Cancer Institute at Webster
Webster, New York 14580, United States

Atrium Health Stanly/LCI-Albemarle
Albemarle, North Carolina 28002, United States

AdventHealth Infusion Center Asheville
Asheville, North Carolina 28803, United States

Rex Hematology Oncology Associates-Cary
Cary, North Carolina 27518, United States

UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina 27599, United States

Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina 28203, United States

Atrium Health Pineville/LCI-Pineville
Charlotte, North Carolina 28210, United States

Levine Cancer Institute-SouthPark
Charlotte, North Carolina 28211, United States

Atrium Health University City/LCI-University
Charlotte, North Carolina 28262, United States

Levine Cancer Institute-Ballantyne
Charlotte, North Carolina 28277, United States

Southeastern Medical Oncology Center-Clinton
Clinton, North Carolina 28328, United States

AdventHealth Infusion Center Haywood
Clyde, North Carolina 28721, United States

Atrium Health Cabarrus/LCI-Concord
Concord, North Carolina 28025, United States

Duke University Medical Center
Durham, North Carolina 27710, United States

Levine Cancer Institute - Rutherford
Forest City, North Carolina 28043, United States

Rex Hematology Oncology Associates-Garner
Garner, North Carolina 27529, United States

Levine Cancer Institute-Gaston
Gastonia, North Carolina 28054, United States

Southeastern Medical Oncology Center-Goldsboro
Goldsboro, North Carolina 27534, United States

AdventHealth Hendersonville
Hendersonville, North Carolina 28792, United States

Southeastern Medical Oncology Center-Jacksonville
Jacksonville, North Carolina 28546, United States

Atrium Health Lincoln/LCI-Lincolnton
Lincolnton, North Carolina 28092, United States

Levine Cancer Institute - Union West
Matthews, North Carolina 28104, United States

Atrium Health Union/LCI-Union
Monroe, North Carolina 28112, United States

FirstHealth of the Carolinas-Moore Regional Hospital
Pinehurst, North Carolina 28374, United States

UNC Rex Healthcare
Raleigh, North Carolina 27607, United States

UNC Rex Cancer Center of Wakefield
Raleigh, North Carolina 27614, United States

Atrium Health Cleveland/LCI-Cleveland
Shelby, North Carolina 28150, United States

AdventHealth Infusion Center Weaverville
Weaverville, North Carolina 28787, United States

Sanford Bismarck Medical Center
Bismarck, North Dakota 58501, United States

Sanford Broadway Medical Center
Fargo, North Dakota 58122, United States

Sanford Roger Maris Cancer Center
Fargo, North Dakota 58122, United States

Summa Health System - Akron Campus
Akron, Ohio 44304, United States

Cleveland Clinic Akron General
Akron, Ohio 44307, United States

Summa Health System - Barberton Campus
Barberton, Ohio 44203, United States

Strecker Cancer Center-Belpre
Belpre, Ohio 45714, United States

Cleveland Clinic Mercy Hospital
Canton, Ohio 44708, United States

Aultman Health Foundation
Canton, Ohio 44710, United States

Miami Valley Hospital South
Centerville, Ohio 45459, United States

Adena Regional Medical Center
Chillicothe, Ohio 45601, United States

Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, Ohio 44111, United States

Cleveland Clinic Foundation
Cleveland, Ohio 44195, United States

Mount Carmel East Hospital
Columbus, Ohio 43213, United States

The Mark H Zangmeister Center
Columbus, Ohio 43219, United States

Dayton Blood and Cancer Center
Dayton, Ohio 45409, United States

Miami Valley Hospital
Dayton, Ohio 45409, United States

Dayton Physician LLC-Miami Valley Hospital North
Dayton, Ohio 45415, United States

Miami Valley Hospital North
Dayton, Ohio 45415, United States

Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio 45005-1066, United States

Miami Valley Cancer Care and Infusion
Greenville, Ohio 45331, United States

Cleveland Clinic Cancer Center Independence
Independence, Ohio 44131, United States

Kettering Medical Center
Kettering, Ohio 45429, United States

Fairfield Medical Center
Lancaster, Ohio 43130, United States

Cleveland Clinic Cancer Center Mansfield
Mansfield, Ohio 44906, United States

Memorial Hospital
Marysville, Ohio 43040, United States

Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio 44124, United States

Summa Health Medina Medical Center
Medina, Ohio 44256, United States

Knox Community Hospital
Mount Vernon, Ohio 43050, United States

Licking Memorial Hospital
Newark, Ohio 43055, United States

Mercy Health Perrysburg Cancer Center
Perrysburg, Ohio 43551, United States

Southern Ohio Medical Center
Portsmouth, Ohio 45662, United States

North Coast Cancer Care
Sandusky, Ohio 44870, United States

Springfield Regional Cancer Center
Springfield, Ohio 45504, United States

Springfield Regional Medical Center
Springfield, Ohio 45505, United States

Trinity's Tony Teramana Cancer Center
Steubenville, Ohio 43952, United States

Cleveland Clinic Cancer Center Strongsville
Strongsville, Ohio 44136, United States

Mercy Health - Saint Anne Hospital
Toledo, Ohio 43623, United States

Toledo Clinic Cancer Centers-Toledo
Toledo, Ohio 43623, United States

Upper Valley Medical Center
Troy, Ohio 45373, United States

South Pointe Hospital
Warrensville Heights, Ohio 44122, United States

Saint Ann's Hospital
Westerville, Ohio 43081, United States

Cleveland Clinic Wooster Family Health and Surgery Center
Wooster, Ohio 44691, United States

Genesis Healthcare System Cancer Care Center
Zanesville, Ohio 43701, United States

University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104, United States

Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma 73120, United States

Legacy Mount Hood Medical Center
Gresham, Oregon 97030, United States

Providence Newberg Medical Center
Newberg, Oregon 97132, United States

Saint Alphonsus Medical Center-Ontario
Ontario, Oregon 97914, United States

Providence Willamette Falls Medical Center
Oregon City, Oregon 97045, United States

Legacy Good Samaritan Hospital and Medical Center
Portland, Oregon 97210, United States

Providence Portland Medical Center
Portland, Oregon 97213, United States

Providence Saint Vincent Medical Center
Portland, Oregon 97225, United States

Kaiser Permanente Northwest
Portland, Oregon 97227, United States

Oregon Health and Science University
Portland, Oregon 97239, United States

Legacy Meridian Park Hospital
Tualatin, Oregon 97062, United States

Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania 18103, United States

UPMC Altoona
Altoona, Pennsylvania 16601, United States

UPMC-Heritage Valley Health System Beaver
Beaver, Pennsylvania 15009, United States

Lehigh Valley Hospital - Muhlenberg
Bethlehem, Pennsylvania 18017, United States

Bryn Mawr Hospital
Bryn Mawr, Pennsylvania 19010, United States

UPMC Hillman Cancer Center at Butler Health System
Butler, Pennsylvania 16001, United States

UPMC Camp Hill
Camp Hill, Pennsylvania 17011, United States

Carlisle Regional Cancer Center
Carlisle, Pennsylvania 17015, United States

WellSpan Medical Oncology and Hematology
Chambersburg, Pennsylvania 17201, United States

Geisinger Medical Center
Danville, Pennsylvania 17822, United States

Pocono Medical Center
East Stroudsburg, Pennsylvania 18301, United States

Ephrata Cancer Center
Ephrata, Pennsylvania 17522, United States

UPMC Hillman Cancer Center Erie
Erie, Pennsylvania 16505, United States

UPMC Cancer Center at UPMC Horizon
Farrell, Pennsylvania 16121, United States

Adams Cancer Center
Gettysburg, Pennsylvania 17325, United States

UPMC Cancer Centers - Arnold Palmer Pavilion
Greensburg, Pennsylvania 15601, United States

UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Harrisburg, Pennsylvania 17109, United States

IRMC Cancer Center
Indiana, Pennsylvania 15701, United States

UPMC-Johnstown/John P. Murtha Regional Cancer Center
Johnstown, Pennsylvania 15901, United States

Lancaster General Ann B Barshinger Cancer Institute
Lancaster, Pennsylvania 17601, United States

Sechler Family Cancer Center
Lebanon, Pennsylvania 17042, United States

UPMC Cancer Center at UPMC McKeesport
McKeesport, Pennsylvania 15132, United States

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
Mechanicsburg, Pennsylvania 17050, United States

Riddle Memorial Hospital
Media, Pennsylvania 19063, United States

UPMC Hillman Cancer Center - Monroeville
Monroeville, Pennsylvania 15146, United States

UPMC Hillman Cancer Center - Part of Frick Hospital
Mount Pleasant, Pennsylvania 15666, United States

Arnold Palmer Cancer Center Medical Oncology Norwin
N. Huntingdon, Pennsylvania 15642, United States

UPMC Cancer Center-Natrona Heights
Natrona Heights, Pennsylvania 15065, United States

UPMC Hillman Cancer Center - New Castle
New Castle, Pennsylvania 16105, United States

Paoli Memorial Hospital
Paoli, Pennsylvania 19301, United States

Thomas Jefferson University Hospital
Philadelphia, Pennsylvania 19107, United States

Jefferson Torresdale Hospital
Philadelphia, Pennsylvania 19114, United States

UPMC-Saint Margaret
Pittsburgh, Pennsylvania 15215, United States

UPMC-Mercy Hospital
Pittsburgh, Pennsylvania 15219, United States

University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania 15232, United States

UPMC-Passavant Hospital
Pittsburgh, Pennsylvania 15237, United States

UPMC-Saint Clair Hospital Cancer Center
Pittsburgh, Pennsylvania 15243, United States

Community Medical Center
Scranton, Pennsylvania 18510, United States

UPMC Cancer Center at UPMC Northwest
Seneca, Pennsylvania 16346, United States

UPMC Cancer Center-Uniontown
Uniontown, Pennsylvania 15401, United States

UPMC Cancer Center-Washington
Washington, Pennsylvania 15301, United States

Chester County Hospital
West Chester, Pennsylvania 19380, United States

Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania 18711, United States

Divine Providence Hospital
Williamsport, Pennsylvania 17754, United States

Asplundh Cancer Pavilion
Willow Grove, Pennsylvania 19090, United States

Lankenau Medical Center
Wynnewood, Pennsylvania 19096, United States

Cancer Care Associates of York
York, Pennsylvania 17403, United States

WellSpan Health-York Cancer Center
York, Pennsylvania 17403, United States

UPMC Memorial
York, Pennsylvania 17408, United States

Smilow Cancer Hospital Care Center - Westerly
Westerly, Rhode Island 02891, United States

AnMed Health Cancer Center
Anderson, South Carolina 29621, United States

Saint Joseph's/Candler - Bluffton Campus
Bluffton, South Carolina 29910, United States

Medical University of South Carolina
Charleston, South Carolina 29425, United States

McLeod Regional Medical Center
Florence, South Carolina 29506, United States

Tidelands Georgetown Memorial Hospital
Georgetown, South Carolina 29440, United States

Gibbs Cancer Center-Pelham
Greer, South Carolina 29651, United States

South Carolina Cancer Specialists PC
Hilton Head Island, South Carolina 29926-3827, United States

Levine Cancer Institute-Rock Hill
Rock Hill, South Carolina 29732, United States

Spartanburg Medical Center
Spartanburg, South Carolina 29303, United States

Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota 57104, United States

Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota 57117-5134, United States

Baptist Memorial Hospital and Cancer Center-Collierville
Collierville, Tennessee 38017, United States

Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee 38120, United States

Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee 37232, United States

The Don and Sybil Harrington Cancer Center
Amarillo, Texas 79106, United States

Houston Methodist San Jacinto Hospital
Baytown, Texas 77521, United States

Dallas VA Medical Center
Dallas, Texas 75216, United States

Tarrant County Hospital District/JPS Health Network
Fort Worth, Texas 76104, United States

Lyndon Baines Johnson General Hospital
Houston, Texas 77026-1967, United States

Houston Methodist Hospital
Houston, Texas 77030, United States

Methodist Willowbrook Hospital
Houston, Texas 77070, United States

Houston Methodist Sugar Land Hospital
Sugar Land, Texas 77479, United States

Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah 84112, United States

Norris Cotton Cancer Center-North
Saint Johnsbury, Vermont 05819, United States

University of Virginia Cancer Center
Charlottesville, Virginia 22908, United States

Centra Lynchburg Hematology-Oncology Clinic Inc
Lynchburg, Virginia 24501, United States

Kaiser Permanente Tysons Corner Medical Center
McLean, Virginia 22102, United States

PeaceHealth Saint Joseph Medical Center
Bellingham, Washington 98225, United States

FHCC South Lake Union
Seattle, Washington 98109, United States

Fred Hutchinson Cancer Research Center
Seattle, Washington 98109, United States

University of Washington Medical Center - Montlake
Seattle, Washington 98195, United States

PeaceHealth United General Medical Center
Sedro-Woolley, Washington 98284, United States

Northwest Medical Specialties PLLC
Tacoma, Washington 98405, United States

Legacy Cancer Institute Medical Oncology and Day Treatment
Vancouver, Washington 98684, United States

Legacy Salmon Creek Hospital
Vancouver, Washington 98686, United States

West Virginia University Charleston Division
Charleston, West Virginia 25304, United States

Edwards Comprehensive Cancer Center
Huntington, West Virginia 25701, United States

West Virginia University Healthcare
Morgantown, West Virginia 26506, United States

Wheeling Hospital/Schiffler Cancer Center
Wheeling, West Virginia 26003, United States

Langlade Hospital and Cancer Center
Antigo, Wisconsin 54409, United States

ThedaCare Regional Cancer Center
Appleton, Wisconsin 54911, United States

Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin 53105, United States

HSHS Sacred Heart Hospital
Eau Claire, Wisconsin 54701, United States

Aurora Health Care Germantown Health Center
Germantown, Wisconsin 53022, United States

Aurora Cancer Care-Grafton
Grafton, Wisconsin 53024, United States

Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin 54301, United States

Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin 54303, United States

Aurora BayCare Medical Center
Green Bay, Wisconsin 54311, United States

Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin 53142, United States

Gundersen Lutheran Medical Center
La Crosse, Wisconsin 54601, United States

University of Wisconsin Carbone Cancer Center
Madison, Wisconsin 53792, United States

Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin 54143, United States

Aspirus Medford Hospital
Medford, Wisconsin 54451, United States

Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin 53209, United States

Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin 53215, United States

Aurora Sinai Medical Center
Milwaukee, Wisconsin 53233, United States

ProHealth D N Greenwald Center
Mukwonago, Wisconsin 53149, United States

ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin 53066, United States

Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls, Wisconsin 54154, United States

Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin 54904, United States

Aurora Cancer Care-Racine
Racine, Wisconsin 53406, United States

Ascension Saint Mary's Hospital
Rhinelander, Wisconsin 54501, United States

Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan, Wisconsin 53081, United States

Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin 53081, United States

Ascension Saint Michael's Hospital
Stevens Point, Wisconsin 54481, United States

Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin 54235-1495, United States

Aurora Medical Center in Summit
Summit, Wisconsin 53066, United States

Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin 54241, United States

ProHealth Waukesha Memorial Hospital
Waukesha, Wisconsin 53188, United States

UW Cancer Center at ProHealth Care
Waukesha, Wisconsin 53188, United States

Aspirus Regional Cancer Center
Wausau, Wisconsin 54401, United States

Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin 53226, United States

Aurora West Allis Medical Center
West Allis, Wisconsin 53227, United States

Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids, Wisconsin 54494, United States

Eligibility

Minimum Age (years)
18
Eligibility Criteria
Inclusion Criteria:

Participants must have histologically or cytologically confirmed non-small cell lung cancer (NSCLC) which is stage IV or recurrent
Participants must have received at least one line of anti-PD-1 or anti-PD-L1 therapy for any stage of NSCLC. Anti-PD-1 or anti-PD-L1 may have been given alone or in combination with other therapy
Participants must have experienced disease progression (in the opinion of the treating physician) more than (>) 84 days following initiation (cycle 1 day 1) of their most recent anti-PD-1 or PD-L1 therapy
Participants who received anti-PD-1 or anti-PD-L1 therapy for stage IV or recurrent disease, must have had a best response on anti-PD-1 or anti-PD-L1 therapy of stable, partial response or complete response (in the opinion of the treating physician)
Participants who received neoadjuvant, adjuvant, and/or consolidation anti-PD-1 or anti-PD-L1 therapy as their only line of anti-PD-1 or anti-PD-L1 therapy must have experienced disease progression within (=<) 365 days from initiation (cycle 1 day 1) of anti-PD-1 or PD-L1 therapy
Participants must have received platinum-based chemotherapy and experienced disease progression (in the opinion of the treating physician) during or after this regimen
Participants with a known sensitizing mutation for which an Food and Drug Administration (FDA)-approved targeted therapy for NSCLC exists (e.g., EGFR, ALK, ROS1, BRAF, RET, NTRK, KRAS, HER2 and MET sensitizing mutations), must have previously received at least one of the approved therapy(s). Prior targeted therapy for participants with targetable alterations is allowed if all other eligibility criteria are also met
Participants must be >= 18 years old
Participants must be able to safely receive the investigational drug combination and the investigator's choice of standard of care regimens per the current FDA approved package insert(s), treating investigator's discretion, and institutional guidelines
Participants must have Zubrod performance status of 0-2

Exclusion Criteria:

Participants must not have received more than one line of anti-PD-1 or anti-PD-L1 for stage IV or recurrent disease
Participants must not be receiving or planning to receive another investigational therapy during study participation

Study Contact Info

Study Contact Name
Site Public Contact; Maya Khalil; Pranitha Prodduturvar; Linda L. Garland; Jay W. Carlson; Rangaswamy Govindarajan; Konstantinos Arnaoutakis; Eric S. Schaefer; Eric C. McGary; John A. Ellerton; Deepti Behl; Karen L. Reckamp; David R. Gandara; Tanyanika L. Phillips; Jennifer M. Suga; Hamid R. Mirshahidi; Jeremy Y. Chuang; Jessica D. McDermott; Sami G. Diab; Alexander Menter; Michael Cohenuram; Wylie D. Hosmer; Salvatore A. Del Prete; Herta H. Chao; Gregory A. Masters; Leon C. Hwang; Stephen V. Liu; Estelamari Rodriguez; Brittany K. Rogers; Sunil Rohatgi; Oleg Gligich; Andreas N. Saltos; I-wen Chang; Nathan C. Tidwell; Charles H. Nash; William E. Burak; Mark A. Taylor; Apurva N. Shah; Samuel N. Ofori; Nicolas Villanueva; John M. Schallenkamp; Charles W. Drescher; Tanmay Sahai; Jason N. Macklis; Bryan A. Faller; Young Kwang Chae; Lawrence E. Feldman; Ariel Polish; Cheryl M. Czerlanis; Nan Sethakorn; Saiama N. Waqar; Muhammad O. Toor; Mario B. Sy; Deborah W. Wilbur; Joshua Lukenbill; Richard L. Deming; Gary C. Doolittle; Dennis F. Moore; David K. Goebel; Susanne M. Arnold; Jewraj G. Maheshwari; Victor T. Lin; Brian C. Boulmay; David Gottlieb; Mayer Gorbaty; Liza C. Villaruz; Paul J. Hesketh; Umit Tapan; John C. McCann; Tareq Al Baghdadi; Angel Qin; Kathleen J. Yost; Matthew L. Ryan; Daniel Almquist; David M. King; Osarenren Ogbeide; Dhruv Bansal; Chao H. Huang; Theodore S. Thomas; Alexander D. Fuld; Polina Khrizman; Missak Haigentz; James W. Lee; Moises Harari-Turquie; Haiying Cheng; Serge Dauphin; Jeffrey M. Stewart; Nicholas Rohs; Stephen L. Graziano; Paul M. Barr; Roger S. Keresztes; Daniel R. Carrizosa; Jennifer L. Heaberlin; Robert S. Wehbie; Carrie Lee; Samer S. Kasbari; Joel Rivera Concepcion; Charles S. Kuzma; Bradley T. Clifford; Judy Peih-Ying Tsai; Timothy D. Moore; Mitchell Haut; Raza A. Khan; Tarek M. Sabagh; Nathan A. Pennell; Howard M. Gross; Rex B. Mowat; Raid Aljumaily; Mei Dong; Sandeep H. Mashru; Jeremy P. Cetnar; Deric C. Savior; Ikechukwu I. Akunyili; Rajiv Panikkar; Samuel J. Kerr; Sarah W. Gordon; Maureen R. Hewitt; John E. Doster; Christopher A. Rangel; Rajesh Bajaj; Michael Humeniuk; Wade Iams; Anita Ravipati; Chinemerem F. Abanonu; Jonathan E. Dowell; Bassam S. Ghabach; Katherine M. Pisters; Sonam Puri; Ryan D. Gentzler; Masey M. Ross; Diane Tseng; Francis M. Senecal; Ahmed A. Khalid; Maria R. Tria Tirona; Mohammed Almubarak; Andrew J. Huang; Qiaofang (lisa) Chen; David E. Marinier; Kari B. Wisinski; Timothy R. Wassenaar
Study Contact Email
tmyrick@uab.edu, pfrancisco@usouthal.edu, UACC-IIT@uacc.arizona.edu, richard.dennis2@va.gov, research@hogonc.com, clinical.trials@kp.org, research@sncrf.org, NCIclinicaltrials@sutterhealth.org, towercancerresearch@toweroncology.com, cancerservices@marshallmedical.org, becomingapatient@coh.org, Kpoct@kp.org, kpoct@kp.org, courtney.steeneken@tmphysicians.com, kristi.m.bronkan@kp.org, protocols@swog.org, canceranswers@yale.edu, research@beebehealthcare.org, lbarone@christianacare.org, trials@cancer.ufl.edu, yenrique@msmc.com, ClinicalTrials@moffitt.org, ClinicalTrials@northside.com, Clinical.trials@northside.com, cancerpatient.navigator@nghs.com, Lorraine.OHara@hcahealthcare.com, underberga@sjchs.org, maryann.heddon@sgmc.org, info@hawaiicancercare.com, i.webster@hawaiicancercare.com, shelley.a.clark@kp.org, stephanie.couch@stjoeshealth.org, eslinget@slhs.org, mccinfo@mtcancer.org, Cancer.Research@rushcopley.com, andersonj@illinoiscancercare.com, cancer@northwestern.edu, advocateresearch@advocate.com, Research@Carle.com, morganthaler.jodi@mhsil.com, Donald.Smith3@nm.org, Barbara.barhamand@advocatehealth.com, Research@carle.com, cancertrials@northwestern.edu, advocateresearch@advocatehealth.com, nctnprogram_rhlccc@northwestern.edu, dschwab@wustl.edu, pallante.beth@mhsil.com, CancerResearch@COMHS.org, mnicholson@comhs.org, kedaprile@rccqc.com, cancerresearch@mercydesmoines.org, Stephanie.Norris@LMH.ORG, Jeni.wakefield@olathehealth.org, BNMathew@freemanhealth.com, mleepers@srhc.com, research@viachristi.org, vanissa.sorrels@owensborohealth.org, clinicalresearch@marybird.com, ann.hooks@tgmc.com, emede1@lsuhsc.edu, pridgely@lifebridgehealth.org, lhmc-cancer-clinical-trials@lahey.org, tamara.wrenn@baystatehealth.org, MCRCwebsitecontactform@stjoeshealth.org, crcwm-regulatory@crcwm.org, karen.forman@ascension.org, ewd_research_admin@hshs.org, wstrong@ghci.org, connie.szczepanek@crcwm.org, OncologyClinicalTrialsFargo@sanfordhealth.org, mmcorc@healthpartners.com, BCCclintrials@bmhcc.org, sfmc@sfmc.net, info@siteman.wustl.edu, aroland@kccop.org, ctsucontact@westat.com, Danielle.Werle@mercy.net, research@billingsclinic.org, cancer.research.nurse@dartmouth.edu, mary.danish@rwjbh.org, joanne.loeb@rwjbh.org, Christine.Kosmides@rwjbh.org, Siby.Varughese@rwjbh.org, Lennette.Gonzales@rwjbh.org, HSC-ClinicalTrialInfo@salud.unm.edu, eskwak@montefiore.org, jgerlach@garnethealth.org, CCTO@mssm.edu, McDowelE@upstate.edu, WCICTOresearch@urmc.rochester.edu, AMBER.WHEELER@AdventHealth.com, CancCtrOncologyClinicalResearch@unchealth.unc.edu, cancerclinicaltrials@med.unc.edu, jfields@cancersmoc.com, jcwilliams@firsthealth.org, cancerresearch@summahealth.org, CancerAnswer@ccf.org, sheree@columbusccop.org, ClinicalReserachDept@aultman.com, clinical.trials@daytonncorp.org, TaussigResearch@ccf.org, ou-clinical-trials@ouhsc.edu, CanRsrchStudies@providence.org, cancer@lhs.org, information@kpchr.org, trials@ohsu.edu, Morgan_M.Horton@lvhn.org, haneydl@upmc.edu, turzoe@mlhs.org, HemonCCTrials@geisinger.edu, klitchfield@PINNACLEHEALTH.org, doxenberg@wellspan.org, ONCTrialNow@jefferson.edu, rhonda.ballew@anmedhealth.org, hcc-clinical-trials@musc.edu, dorie.sturgill@mcleodhealth.org, broe@tidelandshealth.org, kmertz-rivera@gibbscc.org, OncologyClinicTrialsSF@sanfordhealth.org, OncologyClinicalTrialsSF@SanfordHealth.org, Gina.Cravey@bsahs.org, macosta02@jpshealth.org, cancerinfo@hci.utah.edu, cancer.research.nurse@hitchcock.org, uvacancertrials@hscmail.mcc.virginia.edu, Kevin.Patel@centrahealth.com, lkey@peacehealth.org, research@southsoundcare.org, oncologyresearch@lhs.org, Christina.Cole@chhi.org, cancertrialsinfo@hsc.wvu.edu, Juli.Alford@aspirus.org, ResearchDept@thedacare.org, ncorp@aurora.org, cancerctr@gundersenhealth.org, Beth.Knetter@aspirus.org, research.institute@phci.org, Chanda.miller@phci.org
Study Contact Phone
205-934-0220, 251-445-9870, 800-378-9373, 501-257-5583, 501-686-8274, 479-872-8130, 800-398-3996, 702-384-0013, 530-672-7050, 800-826-4673, 877-642-4691, 877-467-3411, 909-558-4050, 310-423-8965, 530-749-4400, 916-734-3089, 310-750-3300, 530-582-6450, 562-698-0811, 888-336-8262, 720-848-0650, 719-365-2406, 719-364-6700, 303-720-2685, 970-297-6150, 970-203-7083, 203-785-5702, 860-545-5363, 866-662-5678, 860-224-5660, 203-323-8944, 203-937-3421, 302-291-6730, 302-623-4450, 301-548-5743, 202-444-2223, 202-877-8839, 954-461-2180, 305-243-2647, 352-273-8675, 863-680-7780, 305-674-2625, 800-679-0775, 404-303-3355, 706-787-2100, 770-219-8800, 912-350-7887, 912-819-5704, 800-648-1935, 229-259-4628, 808-539-2273, 808-486-6000, 808-524-6115, 808-532-0315, 808-545-8548, 808-522-4333, 808-531-8521, 808-432-5195, 734-712-3671, 208-381-2774, 406-969-6060, 630-978-6212, 847-842-4847, 309-243-3605, 312-695-1301, 312-355-3046, 773-878-8200, 773-296-5360, 630-929-6129, 800-446-5532, 217-876-4762, 630-352-5360, 815-285-7800, 630-275-1270, 847-429-2907, 847-570-2109, 708-799-9995, 708-202-8387, 708-226-4357, 800-323-8622, 847-384-3621, 314-747-9912, 217-545-7929, 800-444-7541, 217-528-7541, 219-310-2550, 219-924-8178, 219-947-1795, 219-836-6875, 219-836-3349, 219-934-8869, 800-284-7370, 563-355-7733, 319-365-4673, 319-363-2690, 515-241-3305, 515-358-6613, 785-623-5774, 785-505-2800, 913-355-8000, 785-452-7038, 785-295-8000, 316-291-4774, 606-327-6499, 859-257-3379, 270-691-8094, 225-215-1353, 985-850-6300, 504-210-3539, 443-849-3706, 410-601-6120, 301-816-7218, 240-964-1400, 301-816-7446, 410-847-3000, 410-871-6400, 978-922-3000, 617-638-8265, 781-744-3421, 978-283-4000, 413-794-3565, 734-712-7251, 800-865-1125, 616-391-1230, 313-343-3166, 920-433-8889, 810-762-8038, 517-364-9400, 218-333-5000, 952-993-1517, 901-226-1366, 573-334-2230, 800-600-3606, 314-996-5569, 816-404-4375, 913-948-5588, 800-525-1483, 888-823-5923, 314-525-6042, 314-251-7066, 417-269-4520, 800-996-2663, 800-639-6918, 856-325-6757, 908-994-8000, 732-923-6564, 973-322-2934, 856-247-7395, 732-235-7356, 973-926-7230, 908-685-2481, 732-557-8294, 505-925-0348, 718-379-6866, 607-271-7000, 845-333-1133, 212-824-7309, 315-464-8230, 585-275-5830, 800-862-2215, 315-464-5476, 800-804-9376, 828-650-8037, 919-784-2500, 877-668-0683, 980-442-2000, 919-587-9084, 888-275-3853, 910-587-9084, 980-442-0600, 910-715-3500, 701-323-5760, 701-234-6161, 330-375-4221, 866-223-8100, 800-523-3977, 888-293-4673, 330-363-7274, 937-528-2900, 877-779-7585, 614-488-2118, 937-276-8320, 937-569-7515, 740-687-8863, 740-393-9000, 740-348-4000, 888-874-7000, 800-444-3561, 614-234-5433, 740-454-5232, 405-271-8777, 405-752-3402, 503-413-2150, 503-215-2614, 800-220-4937, 503-335-2400, 503-494-1080, 503-413-1742, 610-402-9543, 412-389-5208, 484-476-2649, 717-975-8900, 717-217-6020, 570-271-5251, 717-721-4840, 877-441-7957, 724-838-1900, 717-724-6765, 814-534-4724, 717-544-0511, 717-741-8303, 412-647-8073, 724-230-3030, 215-600-9151, 412-784-4900, 800-533-8762, 412-367-6454, 412-502-3920, 570-703-4768, 814-676-7900, 610-431-5297, 717-741-9229, 717-724-6760, 864-512-4651, 843-792-9321, 843-777-0770, 843-545-5600, 864-560-6104, 605-312-3320, 800-811-8480, 806-212-1985, 817-702-5913, 713-566-5000, 713-790-2700, 281-242-2873, 888-424-2100, 434-243-6303, 434-200-5925, 240-632-4284, 360-788-8223, 800-804-8824, 360-788-8238, 253-306-0532, 304-388-9944, 304-399-6566, 304-293-7374, 304-243-6442, 715-623-9869, 920-364-3604, 414-302-2304, 608-775-2385, 800-622-8922, 715-847-2353, 262-928-7878, 262-928-7632, 262-928-5539, 877-405-6866, 715-422-7718

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Ramucirumab Plus Pembrolizumab vs Usual Care for Treatment of Stage IV or Recurrent Non-Small Cell Lung Cancer Following Immunotherapy, Pragmatica-Lung Study 0 reviews

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Other Details

FDA Regulated Drug?
Yes
FDA Regulated Device?
No
Detailed Description
PRIMARY OBJECTIVE:

I. To compare overall survival (OS) in participants previously treated with platinum-based chemotherapy and immunotherapy for stage IV or recurrent non-small cell lung cancer (NSCLC) randomized to pembrolizumab and ramucirumab versus standard of care.

SECONDARY OBJECTIVE:

I. To summarize reports of serious and unexpected high-grade (>= grade 3) treatment-related adverse events determined by the treating physician within each treatment arm.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM A: Patients receive chemotherapy per standard of care on study.

ARM B: Patients receive ramucirumab intravenously (IV) and pembrolizumab IV on study.
NCTid (if applicable)
NCT05633602