Neuroblastoma is a malignant tumor that develops in infants and kids. Dysregulation of histone acetylation is associated with a series of malignant tumors. Neuroblastoma is caused by defective neural crest differentiation due to abnormal gene regulation.
Age 3~18 years old;
Patients must have a life expectancy of at least 6 weeks and a Lansky (≤16 years) or Karnofsky (>16 years) score of at least 50;
Histologically confirmed neuroblastoma and/or demonstration of tumor cells in the bone marrow with increased urinary catecholamines;
Patients must have a history of high-risk neuroblastoma, at least one measurable lesions according to the RECIST 1.1;
Patients who have progressed, recurrent or refractory disease after first-line treatment;
The residual disease biopsy must be done, if patiens who have persistent disease obtain incomplete response after first line treatment;
Patients must have fully recovered from the acute toxic effects of all prior chemotherapy, immunotherapy, or radiotherapy prior to study registration；
Patients have not received enzyme-induced anticonvulsant therapy;
Patients have not received valproic acid within 30 days before admission;
ANC ≥ 1.5×10^9/L, PLT ≥75×10^9/L;TBIL≤1.5ULN, ALT and AST≤3×ULN（ALT and AST≤5×ULN if liver metastasis）;BUN and Cr≤1.5×ULN 9）LVEF ≥ 50% and QTc≤470 ms.
Patients' guardians must be willing and able to understand and comply with the protocol for the duration of the study.
Patients with severe cardiovascular disease;
Patients who have previously received organ transplants;
Inability to swallow pills;
Female patients during pregnancy and lactation, fertile women with positive baseline pregnancy tests or women of childbearing age who are unwilling to take effective contraceptive measures throughout the trial;
Active HIV, hepatitis B or hepatitis C;
Researchers believe that patients are unsuitable for any other situation in this study.
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