Virtual Reality-Reward Training for Anhedonia

Save

Report Abuse

Description

The purpose of this study is to compare the effects of Virtual Reality-Reward Training (VR-RT) with an active control condition, Virtual Reality-Memory Training (VR-MT), on positive affect and other clinical symptoms.

VR-Reward Training is a novel intervention aimed at enhancing savoring of positive experiences among individuals with depression and low positive affect through guided imaginal recounting following immersion in positive VR experiences.

Target enrollment is 80 male and female participants with low positive affect, depression, and impaired functioning, who are at least 18 years old, who will be randomly assigned to 7 weeks of either Virtual Reality-Reward Training (VR-RT) or Virtual Reality-Memory Training (VR-MT). Participants will complete in-person VR sessions, laboratory assessments, self-report questionnaires as part of the study.

The total length of participation is around 3 months.

Study Overview

Start Date
September 15, 2022
Completion Date
December 31, 2024
Enrollment
80
Date Posted
April 22, 2022
Accepts Healthy Volunteers?
No
Gender
All

Locations

Full Address
University of California, Los Angeles
Los Angeles, California 90095, United States

Eligibility

Minimum Age (years)
18
Eligibility Criteria
Inclusion Criteria:

At least 18 years old
Fluent in written and spoken English

Meet all of the following dimensional score cutoffs:

Score on the DASS-21 depression subscale must be ≥ 11
Score on the PANAS-P of 24 or lower
Score on the SDS of ≥ 6
Willingness to refrain from initiating other psychosocial treatments throughout the duration of the study

Exclusion Criteria:

Lifetime history of bipolar disorder, psychosis, mental retardation, or organic brain damage
Substance use disorder in the past 6 months
Current use of psychotropic medications
Currently pregnant or planning to become pregnant
Self-reported frequent motion sickness
Self-reported seizures within the last year and/or a diagnosis of epilepsy

Study Contact Info

Study Contact Name
Brooke Cullen, B.A.; Courtney Forbes, Ph.D
Study Contact Phone

Contact Listings Owner Form

Virtual Reality-Reward Training for Anhedonia 0 reviews

Write Your Review

There are no reviews yet.

Write Your Review

Your email address will not be published. Required fields are marked *

Other Details

FDA Regulated Drug?
No
FDA Regulated Device?
No
Detailed Description
Anhedonia, or loss of interest and pleasure in usual activities, has been relatively resistant to pharmacological and psychological treatments in the context of anxiety and depression. Newer treatments that focus upon positivity or reward sensitivity have shown promising results.

The purpose of the current randomized controlled trial is to compare the effects of Virtual Reality-Reward Training (VR-RT) with an active control condition, Virtual Reality-Memory Training (VR-MT), on positive affect and other clinical symptoms. Virtual Reality-Reward Training is designed to augment reward sensitivity in individuals with depression and low positive affect. Targets include behavioral, cognitive, and self-report indices of reward anticipation and initial response to reward. Specificity of target engagement is assessed by comparison with Virtual Reality-Memory Training, designed to improve memory.

Targets and clinical outcomes are assessed at baseline (Week 1) and either weekly or at mid-treatment (Week 3), post-treatment (Week 7), and follow-up (Week 12). Statistical models evaluate whether change in outcomes and change in target measures are greater as a result of Virtual Reality-Reward Training compared to Virtual-Reality-Memory Training and whether changes in target measures correlate with changes in outcome measures.

Target enrollment is 80 male and female participants with low positive affect, depression, and impaired functioning, who are at least 18 years old, who will be randomized to Virtual Reality-Reward Training or Virtual-Reality Memory Training, each comprising 7 individual virtual reality training sessions over the course of 7 weeks.

Participants will complete laboratory tests and self-report questionnaires as part of the study. Total length of participation is around 3 months.
NCTid (if applicable)
NCT05342077